Psoriatic arthritis | Apremilast (Otezla)... new hope for psoriatic arthritis

Author: Nathan Wei

What's new for psoriatic arthritis? Find out next... Apremilast (Otezla)... New hope for psoriatic arthritis The American College of Rheumatology puts out hotlines on new drugs. Here's the one on apremilast. Apremilast is the first oral agent approved by the FDA for the treatment of PsA.

While its efficacy profile is modest compared to biologic therapy, it has a favorable safety profile and the convenience of oral dosing. It may be most appropriate for patients with less severe joint and skin manifestations who may not yet require a biologic DMARD. There are also emerging data in patients with psoriasis only suggesting apremilast is moderately efficacious for controlling skin disease. There are no radiographic data available for apremilast. Although apremilast has not been associated with an increase in overall adverse events, infections, or malignancies, symptoms of depression, including suicidal thoughts/behavior, and weight loss, have been reported. Comment: Safe but not as effective as I would like.

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