Pseudohypoparathyroidism

Author: Audiopedia

Pseudohypoparathyroidism is a condition associated primarily with resistance to the parathyroid hormone. Patients have a low serum calcium and high phosphate, but the parathyroid hormone level is actually appropriately high. Its pathogenesis has been linked to dysfunctional G Proteins. The condition is extremely rare, with an estimated overall prevalence of 7.2/1,000,000 or approximately 1/140000. Types Types include: While biochemically similar, type 1 and 2 disease may be distinguished by the differing urinary excretion of cyclic AMP in response to exogenous PTH. Some sources also refer to a "type 1c". Related conditions The term pseudopseudohypoparathyroidism is used to describe a condition where the individual has the phenotypic appearance of pseudohypoparathyroidism type 1a, but is biochemically normal. Presentation and differential Patients may present with features of hypocalcaemia including carpo-pedal muscular spasms, cramping, tetany, and if the calcium deficit is severe, generalized seizures.

IQ is typically mildly depressed or unaffected. Additional characteristics include short stature, obesity, developmental delay, and calcification of the basal ganglia in the deep white matter of the brain. Type 1a Pseudohypoparathyroidism is clinically manifest by bone resorption with blunting of the fourth and fifth knuckles of the hand, most notable when the dorsum of the hand is viewed in closed fist position. This presentation is known as 'knuckle knuckle dimple dimple' sign. This is as opposed to Turner syndrome which is characterized by blunting of only the fourth knuckle, and Down's syndrome, which is associated with a hypoplastic middle phalanx. Biochemical Findings hypocalcemia hyperphosphatemia elevated parathyroid hormone Supressed calcitriol levels See also Hypoparathyroidism Pseudopseudohypoparathyroidism Hyperparathyroidism Rickets Hypervitaminosis D References.

Pseudohypoparathyroidism

Pseudohypoparathyroidism is a condition associated primarily with resistance to the parathyroid hormone. Patients have a low serum calcium and high phosphate, but the parathyroid hormone…

By: Audiopedia
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By: Audiopedia