ProGraft: The Proactive Solution to a Long-Lasting Hemodialysis Graft

Author: Weldon School of Biomedical Engineering

(light music) - [Narrator] For over 500,000 Americans who have end-stage renal disease, hemodialysis is a way of life. These four hour sessions of filtering their blood occur three to five times a week and the success of these treatments depends on a surgically-placed vascular access device such as an arterial-venous fistula and graft. - Arterial-venous grafts are used in a sizable proportion of the chronic hemodialysis population, about 20%. The two biggest problems with the arterial-venous graft are number one, frequent thrombosis and stenosis and secondly, infection. - [Narrator] With an estimated three billion dollars spent in the US solely on vascular access creation and maintenance every year, there is a clear need to improve the graft design to increase longevity of these devices and prevent patients from requiring additional surgeries.

ProGraft is a proactive device that'll use a two-pronged approach. By using actuators and resealable access ports, the ProGraft will prevent the buildup of cells along the interior walls and reduce trauma to a device for repeated needle punctures that occur during each treatment. The actuators oscillate due to an externally applied electromagnetic field, which has been proven through new cell growth. In conjunction with the resealable access ports that will withstand over two years worth of needle punctures, the possibility of cell growth inside the graft is diminished. - If you could give us a part of the graft that would tolerate repeated needle punctures and seal without significant leak, and not fall apart in 500 say or 300 to 500 punctures, that would be, I think, ideal. I do think the actuators is interesting. If in fact it avoided stenosis evac, that would be marketable as well.

But I think the combination of those two would be even more valuable. - [Narrator] Working closely with Purdue faculty member Dr. Hugh Lee and two nephrologists, Dr. Stephen Ash and Dr. William Clark, our team of biomedical engineering students at Purdue University is confident in the potential impact of this innovative technology. The next steps will be animal testing and incorporating our technology into existing dialysis graft designs for clinical trials.

We are looking for investors with experience in the medical field to help us proactively enhance the lives of dialysis patients all around the globe.

ProGraft: The Proactive Solution to a Long-Lasting Hemodialysis Graft

ProGraft: The Proactive Solution to a Long-Lasting Hemodialysis Graft

(light music) - [Narrator] For over 500,000 Americans who have end-stage renal disease, hemodialysis is a way of life. These four hour sessions of filtering their blood occur three…

By: Weldon School of Biomedical Engineering
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