Photodynamic Therapy (PDT) for Skin Cancer • Oncolex
This is a video of photodynamic therapy on a patient with basal cell carcinoma. Photdynamic therapy is a two step procedure First the lesion is scraped with a curette, and covered with a cream containg the photosensitising agent methyl aminolevulinate. The lesion is then exposed to red light. The patient has multiple superficial lesions on hisback. The surface of the lesions is gently scraped with a curette. The tumor tissue bleeds easily, but the surrounding healthy skin, remains intact. After scraping, the cream is applied to the lesions. This will now be absorbed effectively by the tumor cells.
The active ingredient of the cream makes the cells sensitive to red light. The cream is allowed to work for three hours before the light treatment. In this period the lesions are covered with plastic film and sponges. This is a different patient.
He has a six centimeter large lesion medially on his back. He also has a nodular lesion laterally to the left of this. The large lesion is scraped. The nodular lesion is thick, so local anasthesia is administered before scraping. The lesion apperas a a raised polyp-like skin abnormality.
By scraping, the tumor characteristically comes of in one piece. The cream is applied to the lesion and it is covered. After three hours, the lesion is ready to be exposed to the red light.
A sponge is palced around the lesion, to reduce the heat exposure to the healthy skin. The lesion is exposed to red light for approximately eight minutes. By exposing the cells to light, singlet oxygen is formed. This causes damage to mitochondria in cell membrane.
Leading to cell death.
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