This article concerns ischemia of the small bowel. See ischemic colitis for ischemia of the large bowel Mesenteric ischemia, also known as mesenteric vascular disease, is a medical condition in which injury of the small intestine occurs due to not enough blood supply. It can come on suddenly, known as acute mesenteric ischemia, or gradually, known as chronic mesenteric ischemia.
Acute disease often presents with sudden severe pain. Symptoms may come on more slowly in those with acute on chronic disease. Signs and symptoms of chronic disease include abdominal pain after eating, unintentional weight loss, vomiting, and being afraid of eating. Risk factors include atrial fibrillation, heart failure, chronic renal failure, being prone to forming blood clots, and previous myocardial infarction. There are four mechanisms by which poor blood flow occurs: a blood clot from elsewhere getting lodged in an artery, a new blood clot forming in an artery, a blood clot forming in the mesenteric vein, and insufficient blood flow due to low blood pressure or spasms of arteries. Chronic disease is a risk factor for acute disease. The best method of diagnosis is angiography, with computer tomography being used when that is not available.
Treatment of acute ischemia may include stenting or medications to break down the clot provided at the site of obstruction by interventional radiology. Open surgery may also be used to remove or bypass the obstruction and may be required to remove any intestines that may have died. If not rapidly treated outcomes are often poor. Among those affected even with treatment the risk of death is 70% to 90%. In those with chronic disease bypass surgery is the treatment of choice. Those who have thrombosis of the vein may be treated with anticoagulation such as heparin and warfarin, with surgery used if they do not improve. Acute mesenteric ischemia affects about five per hundred thousand people per year in the developed world.
Chronic mesenteric ischemia affects about one per hundred thousand people. Most people affected are over 60 years old. Rates are about equal in males and females of the same age. Mesenteric ischemia was first described in 1895.
Signs and symptoms Three progressive phases of ischemic colitis have been described: A hyper active stage occurs first, in which the primary symptoms are severe abdominal pain and the passage of bloody stools. Many patients get better and do not progress beyond this phase. A paralytic phase can follow if ischemia continues; in this phase, the abdominal pain becomes more widespread, the belly becomes more tender to the touch, and bowel motility decreases, resulting in abdominal bloating, no further bloody stools, and absent bowel sounds on exam. Finally, a shock phase can develop as fluids start to leak through the damaged colon lining. This can result in shock and metabolic acidosis with dehydration, low blood pressure, rapid heart rate, and confusion. Patients who progress to this phase are often critically ill and require intensive care.
= Clinical findings = Symptoms of mesenteric ischemia vary and can be acute, subacute, or chronic. Case series report prevalence of clinical findings and provide the best available, yet biased, estimate of the sensitivity of clinical findings. In a series of 58 patients with mesenteric ischemia due to mixed causes: abdominal pain was present in 95%. The other three patients presented with shock and metabolic acidosis. Nausea in 44% vomiting in 35% diarrhea in 35% heart rate 100 in 33% 'blood per rectum' in 16% constipation 7% = Diagnostic heuristics = In the absence of adequate quantitative studies to guide diagnosis, various heuristics help guide diagnosis: Mesenteric ischemia "should be suspected when individuals, especially those at high risk for acute mesenteric ischemia, develop severe and persisting abdominal pain that is disproportionate to their abdominal findings" Regarding mesenteric arterial thrombosis or embolism: "...early symptoms are present and are relative mild in 50% of cases for three to four days before medical attention is sought". Regarding mesenteric arterial thrombosis or embolism: "Any patient with an arrhythmia such as atrial fibrillation who complains of abdominal pain is highly suspected of having embolization to the superior mesenteric artery until proved otherwise". Regarding nonocclusive intestinal ischemia: "Any patient who takes digitalis and diuretics and who complains of abdominal pain must be considered to have nonocclusive ischemia until proved otherwise". Diagnosis It is difficult to diagnose mesenteric ischemia early.
One must also differentiate ischemic colitis, which often resolves on its own, from the more immediately life-threatening condition of acute mesenteric ischemia of the small bowel. = Blood tests = In a series of 58 patients with mesenteric ischemia due to mixed causes: White blood cell count 10.5 in 98% Lactic acid elevated 91% = During endoscopy = A number of devices have been used to assess the sufficiency of oxygen delivery to the colon. The earliest devices were based on tonometry, and required time to equilibrate and estimate the pHi, roughly an estimate of local CO2 levels. The first device approved by the U.S. FDA used visible light spectroscopy to analyze capillary oxygen levels. Use during Aortic Aneurysm repair detected when colon oxygen levels fell below sustainable levels, allowing real-time repair. In several studies, specificity has been 83% for chronic mesenteric ischemia and 90% or higher for acute colonic ischemia, with a sensitivity of 71%-92%.
This device must be placed using endoscopy, however. = Plain x-ray = Plain X-rays are often normal or show non-specific findings. = Computed tomography = Computed tomography is often used. The accuracy of the CT scan depends on whether a small bowel obstruction is present. SBO absent prevalence of mesenteric ischemia 23% sensitivity 64% specificity 92% positive predictive value 79% negative predictive value 95% SBO present prevalence of mesenteric ischemia 62% sensitivity 83% specificity 93% positive predictive value 93% negative predictive value 61% Findings on CT scan include: Mesenteric edema Bowel dilatation Bowel wall thickening Intramural gas Mesenteric stranding = Angiography = As the cause of the ischemia can be due to embolic or thrombotic occlusion of the mesenteric vessels or nonocclusive ichemia, the best way to differentiate between the etiologies is through the use of mesenteric angiography.
Though it has serious risks, angiography provides the possibility of direct infusion of vasodilators in the setting of nonocclusive ischemia Treatment NG tube decompression, angiogram for diagnosis and treatment, heparin anticoagulation. Papaverine to decrease arterial vasospasm. "Surgical revascularisation remains the treatment of choice for mesenteric ischaemia, but thrombolytic medical treatment and vascular interventional radiological techniques have a growing role".
If the ischemia has progressed to the point that the affected intestinal segments are not savable, a bowel resection of those segments is called for. Often, obviously dead segments are removed at the first operation, and a second-look operation is planned to assess segments that are borderline that may be savable after revascularization. Prognosis The prognosis depends on prompt diagnosis and the underlying cause: venous thrombosis - 32% mortality arterial embolism - 54% mortality arterial thrombosis - 77% mortality non-occlusive ischemia - 73% mortality History Acute mesenteric ischemia was first described in 1895 while chronic disease was first described in the 1940s. Chronic disease was initially known as angina abdominis.
Language In British English it is spelled mesenteric ischaemia. References.
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